Clinical Studies

The pH of the skin surface and its impact on the barrier function.

Departments of Dermatology and Allergology, Rheinische Friedrich Wilhelm University, Bonn, Germany. Monika-Hildegard.Schmid-Wendtner@ukbuni-bonn.de

Females have lower skin surface pH than men. A study on the surface of gender, forearm site variation, right/left difference and time of the day on the skin surface pH.

University of Copenhagen, School of Medicine, Denmark.

New wrinkles on wrinkling: an 8-year longitudinal study on the progression of expression lines into persistent wrinkles

2010 G.G. Hillebrand, Z. Liang, X. Yan and T. Yoshii

Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants 

Department of Pediatrics, University of Vienna, School of Medicine, Austria.

Measurement of skin pH.

Unit of Cell Pharmacology, School of Pharmacy, Israel.

Skin pH: from basic science to basic skin care.

Saba M. AlI and Gil Yosipovitch Department of Dermatology, Wake Forest University Baptist Medical Center, Winston-Salem, USA

Correlation between pH and irritant effect of cleansers marketed for dry skin.

Servicio de Dermatología Hospital Central Ignacio Morones Prieto, San Luis Potosí, México. baranda@uaslp.mx

Progression of temporary into persistent facial wrinkling: An 8-year longitudinal study.

G.G. Hillebrand, Z. Liang,* X. Yan* and T. Yoshii The Procter & Gamble Company, Cincinnati, OH 45241, U.S.A.

A Guide to the Ingredients and Potential Benefits of Over-The-Counter Cleansers and Moisturizers for Rosacea Patients

Jacquelyn Levin, Do; Richard Miller; Do Largo Medical Center, Largo, Florida; bNova Southeastern University College of Osteopathic Medicine and Largo Medical Center, Largo, Florida

The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation.

Skin Research Institute, R&D Center, Amore Pacific Corporation, 314-1, 446-729 Bora-dong Giheung-gu Yongin-Si Gyeonggi-do, Korea. eon827@amorepacific.com

Natural skin surface pH is on average below 5, which is beneficial for its resident flora.

Sara Lee Household and Body Care Research, Fruitweg, The Hague, The Netherlands.

Effect of skin pH for wrinkle formation on Asian: Korean, Vietnamese and Singaporean.

 Amorepacific Corporation R&D Center, 314-1, Bora-dong Giheung-gu Yongin-si Gyeonggi-do, 446-729, Korea Division of Chemical Engineering, College of Engineering, Hanyang University, Seoul

Treatment of Aged Skin with a pH 4 Skin Care Product Normalizes Increased Skin Surface pH and Improves Barrier Function: Results of a Pilot Study.

 Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany; 2Research and Development, Kneipp-Werke, Würzburg, Germany. Email: jblaak@uni-osnabrueck.de

Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline-controlled clinical study.

2013 Department of Dermatology, The 3rd Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

An Updated Review of Tyrosinase Inhibitors

2009 Department of Biological Science and Technology, National University of Tainan, 33 sec. 2 Shu-Lin St., Tainan, Taiwan; E-Mail: mozyme2001@yahoo.com.tw; Tel. +886 6 2606283; Fax: +886 6 2909502

Anti-angiogenic effects of epigallocatechin-3-gallate in human skin

2010 1University Hospitals Case Medical Center, Departments of Dermatology, Cleveland, OH 44106, USA

Innovations in natural ingredients and their use in skin care.

2010 University of Louisville, Division of Dermatology, Louisville, KY 40202, USA. fowlerjoe@msn.com

Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all

2010 Department of Pharmacology, Maliba Pharmacy College, Bardoli-394 350, India Department of Pharmacology, Institute of Pharmacy, Nirma University (NU), Ahmedabad-382 481, India

The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging.

 2004 DakDak Photoaging Technologies, Division of Charles River Laboratories, Inc., Pennsylvania College of Optometry, Elkins Park KGL Inc., Ivy Laboratories University City Science Center, Philadelphia, Pennsylvania, USA.

Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine.

2007 Procter & Gamble Company, Cincinnati, Ohio 45252, USA. bissett.dl@pg.com

A single centre study in 21 healthy female volunteers (aged between 25-65 years) to evaluate the relative degree of one cleanser product compared to a standard facial cleanser and a positive control, as measured by trans epidermal water loss (TEWL) assessments.

Performed by Princeton Clinical Research Corp, United Kingdom, 2017.

A user trial study in 22 healthy female panelists ages 25-65, to evaluate the efficacy of a Detoxifying Gel Cleanser in changing skin pH vs. standard cleanser and to evaluate the efficacy by utilizing self-perception questionnaires.

Performed by Princeton Clinical Research Corp, Florida, 2017.

A home use study in 22 healthy females between ages 30-70, to evaluate the efficacy of a Regenerating Night Cream by utilizing self-perception questionnaires.

Performed by Princeton Consumer Research Corp, Florida, 2017.

A home use study in 22 healthy females between ages 30-65, to evaluate the efficacy of a Clarifying Serum by utilizing self-perception questionnaires.

Performed by Princeton Consumer Research Corp, Florida, 2017.

A home use study in 22 healthy females between ages 30-70, to evaluate the efficacy of a Soothing Day Cream + Primer SPF 46 by utilizing self-perception questionnaires.

Performed by Princeton Consumer Research Corp, Florida, 2017.

A clinical study in 22 healthy female panelists ages 40-70, to evaluate the efficacy of an Illuminating Serum through instrument tests, expert grading and utilizing self-perception questionnaires.

Performed by Princeton Consumer Research Corp, Florida, 2017.

The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?

2012 University of Alberta, Suite No. 301, 9509-156 Street, Edmonton, AB, Canada T5P 4J5 Gerry K. Schwalfenberg

Dietary nutrient intakes and skin-aging appearance among middle-aged American women.

2007 Corporate Research, Unilever Colworth Park, Bedford, United Kingdom. maeve.cosgrove@unilever.com